{(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

Base Information

Chemical Name:{(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester
CAS No.:116400-01-2
Molecular Formula:C₂₃H₄₂O₄Si
Molecular Weight:410.67
Hs Code.:

Synonyms:{(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

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Chemical Property of {(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

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Technology Process of {(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

There total 8 articles about {(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 116399-92-9
2,5,5-trimethyl-2-<2'-<4''-(carboxymethyl)-1''(R)-methyl-3''-<(trimethylsilyl)methylene>cyclohex-2''-yl>ethyl>-1,3-dioxane

: 77-78-1
dimethyl sulfate

: 116400-01-2
{(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

Guidance literature:: With potassium carbonate; In acetone;
DOI:10.1016/S0040-4039(00)96582-1

Reference yield:

: 116399-89-4
2,5,5-trimethyl-2-<2'-(1''(R)-methyl-3''-oxocyclohex-2''-yl)ethyl>-1,3-dioxane

: 116400-01-2
{(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / pyridine / tetrahydrofuran / Heating

2: 1.) n-BuLi, TMEDA, 2.) DMF

3: 1.) Et₂O, pentane, -78 deg C, 2.) DMAP, 20 deg C

4: 56 percent / LICA / tetrahydrofuran / -78 deg C to 20 deg C

5: 94 percent / K₂CO₃ / acetone

With pyridine; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium cyclohexylisopropylamide; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4039(00)96582-1

Reference yield:

: 87842-52-2
2-(2,5,5-trimethyl-1,3-dioxan-2-yl)ethyl bromide

: 116400-01-2
{(1S,3S,4R)-4-Methyl-3-[2-(2,5,5-trimethyl-[1,3]dioxan-2-yl)-ethyl]-2-[1-trimethylsilanyl-meth-(Z)-ylidene]-cyclohexyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA, HMPA / 1.) THF, -78 deg C

2: Al(Hg) / tetrahydrofuran; H₂O

3: 94 percent / pyridine / tetrahydrofuran / Heating

4: 1.) n-BuLi, TMEDA, 2.) DMF

5: 1.) Et₂O, pentane, -78 deg C, 2.) DMAP, 20 deg C

6: 56 percent / LICA / tetrahydrofuran / -78 deg C to 20 deg C

7: 94 percent / K₂CO₃ / acetone

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; aluminum amalgam; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium cyclohexylisopropylamide; potassium carbonate; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; water; acetone;
DOI:10.1016/S0040-4039(00)96582-1