1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester
• CAS No.: 96429-63-9
• Molecular Formula: C₁₈H₁₉N₃O₄
• Molecular Weight: 341.367

Synonyms:1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

Chemical Property of 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

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Technology Process of 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

There total 3 articles about 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-Benzoyl-1,3-dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester (96429-57-1) → 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester (96429-63-9)

Guidance literature:

With hydrogenchloride; In ethanol; for 1.5h; Heating;

DOI:10.1021/jo00214a002

Reference yield: 78.0%

6,8-Dimethyl-4-oxy-3-p-tolyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione (96429-52-6) + acetylenedicarboxylic acid diethyl ester (762-21-0) → 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester (96429-63-9)

Guidance literature:

In toluene; at 95 ℃; for 0.5h;

DOI:10.1021/jo00214a002

Reference yield:

6,8-Dimethyl-4-oxy-3-p-tolyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione (96429-52-6) → 1,3-Dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester (96429-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / toluene / 3 h / 120 °C

2: 97 percent / 10percent aq. HCl / ethanol / 1.5 h / Heating

With hydrogenchloride; In ethanol; toluene;

DOI:10.1021/jo00214a002

upstream raw materials:

5-Benzoyl-1,3-dimethyl-2,4-dioxo-6-p-tolyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

6,8-Dimethyl-4-oxy-3-p-tolyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione

acetylenedicarboxylic acid diethyl ester

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