N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

Base Information

Chemical Name:N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide
CAS No.:1328623-67-1
Molecular Formula:C₂₃H₂₀ClN₇O₃
Molecular Weight:477.91
Hs Code.:

Synonyms:N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

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Chemical Property of N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

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Technology Process of N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

There total 10 articles about N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1328623-74-0
5-(4-aminomethyloxazol-2-yl)-N⁽⁴⁾-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)pyrimidin-4,6-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1328623-67-1
N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃; for 0.166667h;

Reference yield:

: 5305-40-8
2,6-dichloro-pyrimidine carbaldehyde

: 1328623-67-1
N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuryl dichloride / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1.5 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

3.1: ammonia / toluene; ethanol / 60 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 0 °C

4.2: pH 8

5.1: hydrogenchloride / 1,4-dioxane; tert-butyl alcohol / 1.5 h / 70 °C

6.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2.33 h / -40 - 20 °C

7.1: lithium aluminium tetrahydride / dichloromethane; diethyl ether / 1 h / 0 °C

7.2: 1 h

8.1: sodium azide; triphenylphosphine / N,N-dimethyl-formamide; tetrachloromethane / 0.5 h / 90 °C

8.2: 2 h / 60 °C

9.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0.17 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; sulfuryl dichloride; Bromotrichloromethane; diethylamino-sulfur trifluoride; ammonia; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 87600-97-3
4,6-dichloropyrimidine-5-carboxylic acid chloride

: 1328623-67-1
N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

2.1: ammonia / toluene; ethanol / 60 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 0 °C

3.2: pH 8

4.1: hydrogenchloride / 1,4-dioxane; tert-butyl alcohol / 1.5 h / 70 °C

5.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2.33 h / -40 - 20 °C

6.1: lithium aluminium tetrahydride / dichloromethane; diethyl ether / 1 h / 0 °C

6.2: 1 h

7.1: sodium azide; triphenylphosphine / N,N-dimethyl-formamide; tetrachloromethane / 0.5 h / 90 °C

7.2: 2 h / 60 °C

8.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0.17 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium azide; Bromotrichloromethane; diethylamino-sulfur trifluoride; ammonia; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;