4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide

Base Information

• Chemical Name: 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide
• CAS No.: 1269421-75-1
• Molecular Formula: C₁₈H₁₅Cl₃N₄O₃S
• Molecular Weight: 473.767
• Mol file: 1269421-75-1.mol

Synonyms:4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide

Chemical Property of 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide

There total 4 articles about 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-chloroquinazoline-8-carbonyl chloride (1093960-58-7) + N-(3-amino-2,4-dichlorophenyl)propane-1-sulfonamide (1269421-19-3) → 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide (1269421-75-1)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 1h; Molecular sieve;

Reference yield:

5-amino-2,6-dichloro-benzoic acid (50917-29-8) → 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide (1269421-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 6 h / 20 °C

2.2: Reflux

3.1: pyridine / chloroform / 1 h / 20 °C / Molecular sieve

With pyridine; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; 2.2: Curtius Rearrangement;

Reference yield:

2,6-dichloro-3-(propylsulfonamido)benzoic acid (1186194-25-1) → 4-chloro-N-(2,6-dichloro-3-(propylsulfonamido)phenyl)quinazoline-8-carboxamide (1269421-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 6 h / 20 °C

1.2: Reflux

2.1: pyridine / chloroform / 1 h / 20 °C / Molecular sieve

With pyridine; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; chloroform; 1.2: Curtius Rearrangement;

upstream raw materials:

5-amino-2,6-dichloro-benzoic acid

4-chloroquinazoline-8-carbonyl chloride

N-(3-amino-2,4-dichlorophenyl)propane-1-sulfonamide

2,6-dichloro-3-(propylsulfonamido)benzoic acid

Downstream raw materials:

4-amino-quinazoline-8-carboxylic acid [2,6-dichloro-3-(propane-1-sulfonylamino)-phenyl]-amide