diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

Base Information

Chemical Name:diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate
CAS No.:1428527-74-5
Molecular Formula:C₂₂H₂₆N₅O₅P
Molecular Weight:471.453
Hs Code.:

Synonyms:diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

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Chemical Property of diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

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Technology Process of diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

There total 5 articles about diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428527-73-4
N-(2-(4-bromophenyl)propan-2-yl)-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide

: 762-04-9
phosphonic acid diethyl ester

: 1428527-74-5
diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; Reflux;

Reference yield:

: 106861-14-7
2-[(4-methylphenyl)sulfonyl]-2,3-dihydropyridazine-3-carbonitrile

: 1428527-74-5
diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 20 °C

2.2: 3 h / Reflux

3.1: sodium methylate / methanol / Reflux

3.2: 4 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 53896-49-4
pyridazine-3-carbonitrile

: 1428527-74-5
diethyl 4-(2-(4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamido)propan-2-yl)phenylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 20 °C

1.2: 3 h / Reflux

2.1: sodium methylate / methanol / Reflux

2.2: 4 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide; toluene;