2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1393900-48-5
Molecular Formula:C₂₇H₃₁F₃N₆O
Molecular Weight:512.578
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Suppliers and Price of 2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 13 articles about 2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1393900-39-4
2-(2-(2-(2-((4-(piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

: 75-07-0,9002-91-9
acetaldehyde

: 1393900-48-5
2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: With methanol; sodium tris(acetoxy)borohydride; In water; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 1393900-48-5
2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 42 h / 20 °C / Inert atmosphere

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

2.2: 18 h / 0 - 20 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 18 h / 20 °C / Inert atmosphere; sealed tube

5.1: water; lithium hydroxide monohydrate / ethanol; tetrahydrofuran / 3 h / 40 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

8.1: sodium tris(acetoxy)borohydride; methanol / water / 18 h / 20 °C / Inert atmosphere

With methanol; lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

: 1393900-48-5
2-(2-(2-(2-((4-(4-ethylpiperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.83 h / 0 °C

1.2: 18 h / 0 - 20 °C

2.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; microwave irradiation

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 18 h / 20 °C / Inert atmosphere; sealed tube

4.1: water; lithium hydroxide monohydrate / ethanol; tetrahydrofuran / 3 h / 40 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

7.1: sodium tris(acetoxy)borohydride; methanol / water / 18 h / 20 °C / Inert atmosphere

With methanol; lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;