(2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

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Chemical Name:(2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
CAS No.:1360568-81-5
Molecular Formula:C₂₉H₃₉ClO₇
Molecular Weight:535.077
Hs Code.:

Synonyms:(2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

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Chemical Property of (2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

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Technology Process of (2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

There total 6 articles about (2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1360568-82-6
C₂₉H₃₉ClO₇

: 1360568-81-5
(2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 16 h / 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 120 °C

4.1: tert.-butyl lithium / tetrahydrofuran; toluene / 2 h / -78 °C

4.2: 2 h / -78 °C

With triethylsilane; boron trifluoride diethyl etherate; tert.-butyl lithium; caesium carbonate; aluminum (III) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1360568-80-4
4-bromo-1-chloro-2-(4-((1-ethylcyclohexyl)methoxy)benzyl)benzene

: 32469-28-6,55515-28-1,55515-29-2,32384-65-9
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

: 1360568-82-6
C₂₉H₃₉ClO₇

: 1360568-81-5
(2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: 4-bromo-1-chloro-2-(4-((1-ethylcyclohexyl)methoxy)benzyl)benzene; (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; With tert.-butyl lithium; In tetrahydrofuran; toluene; at -78 ℃; for 2h;

With methanesulfonic acid; In tetrahydrofuran; toluene; at -78 ℃; for 2h;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1360568-82-6
C₂₉H₃₉ClO₇

: 1360568-81-5
(2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-ethylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C

3.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 16 h / 20 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 120 °C

6.1: tert.-butyl lithium / tetrahydrofuran; toluene / 2 h / -78 °C

6.2: 2 h / -78 °C

With triethylsilane; thionyl chloride; boron trifluoride diethyl etherate; tert.-butyl lithium; caesium carbonate; aluminum (III) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;