ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Base Information

• Chemical Name: ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate
• CAS No.: 879220-60-7
• Molecular Formula: C₁₇H₂₃F₂NO₄
• Molecular Weight: 343.371
• Mol file: 879220-60-7.mol

Synonyms:ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Chemical Property of ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate

There total 2 articles about ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetaldehyde (122-78-1) → ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate (879220-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / 0 °C

1.2: 52.3 percent / Et₂Zn / Wilkinson's catalyst / tetrahydrofuran; hexane / 0.5 h / 0 °C

2.1: 76.4 percent / H₂ / Pd(OH)2/C / ethanol / 24 h / 20 °C

With hydrogen; palladium dihydroxide; In tetrahydrofuran; ethanol;

DOI:10.1021/ol052781k

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + C12H15F2NO2 → ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate (879220-60-7)

Guidance literature:

In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/jo900134k

Reference yield:

ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate (879220-60-7) → (1-benzyl-2,2-difluoro-3-oxo-propyl)-carbamic acid tert-butyl ester

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.5h;

DOI:10.1021/ol052781k

upstream raw materials:

phenylacetaldehyde

di-tert-butyl dicarbonate

Downstream raw materials:

(6S)-6-benzyl-3,6-dihydro-5-fluoro-1H-pyridin-2-one

(6S)-6-benzyl-5,5-difluoro-5,6-dihydropyridin-2(1H)-one

tert-butyl (5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-4-fluoro-6-phenylhex-3-enoate

tert-butyl (5S,2Z)-5-[N-(tert-butoxycarbonyl)amino]-4,4-difluoro-6-phenylhex-2-enoate