7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

Base Information

Chemical Name:7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester
CAS No.:199102-76-6
Molecular Formula:C₃₀H₂₉ClN₂O₆S
Molecular Weight:581.089
Hs Code.:

7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2<i>H</i>-thieno[2,3-<i>b</i>;5,4-<i>b</i>']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

Synonyms:7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

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Chemical Property of 7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

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Technology Process of 7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

There total 3 articles about 7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 638-07-3
ethyl (2-chloroaceto)acetate

: 199102-72-2
2-amino-7-benzyloxycarbonyl-3-(3,4-dimethoxybenzoyl)-4,5,6,7-tetrahydrothieno[2,3-b]pyridine

: 199102-76-6
7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

Guidance literature:: With sulfuric acid; acetic acid; at 100 ℃;
DOI:10.1248/cpb.47.993

Reference yield:

: 61995-20-8
N-(benzyloxycarbonyl)-3-piperidone

: 199102-76-6
7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 16 percent / S; morpholine / ethanol / Heating

2: 79 percent / conc. H₂SO₄; AcOH / 100 °C

With morpholine; sulfuric acid; sulfur; acetic acid; In ethanol; 1: Gewald reaction / 2: Friedlaender reaction;
DOI:10.1248/cpb.47.993

Reference yield:

: 4640-69-1
ω-cyano-3,4-dimethoxyacetophenone

: 199102-76-6
7-chloromethyl-5-(3,4-dimethoxy-phenyl)-3,4-dihydro-2H-thieno[2,3-b;5,4-b']dipyridine-1,6-dicarboxylic acid 1-benzyl ester 6-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 16 percent / S; morpholine / ethanol / Heating

2: 79 percent / conc. H₂SO₄; AcOH / 100 °C

With morpholine; sulfuric acid; sulfur; acetic acid; In ethanol; 1: Gewald reaction / 2: Friedlaender reaction;
DOI:10.1248/cpb.47.993