methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

Base Information

Chemical Name:methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate
CAS No.:1421329-68-1
Molecular Formula:C₂₃H₂₂N₄O₃S
Molecular Weight:434.519
Hs Code.:

Synonyms:methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

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Chemical Property of methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

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Technology Process of methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

There total 5 articles about methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1421329-54-5
methyl 3-(1-(3-bromo-4-(4-methoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate

: 30418-59-8,280563-63-5
3-Aminophenylboronic acid

: 1421329-68-1
methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

Guidance literature:: With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; cesium fluoride; In N,N-dimethyl-formamide; at 90 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2012.11.070

Reference yield:

: 1421329-52-3
methyl 3-(1-(3-bromo-4-cyanophenyl)-1H-imidazol-2-yl)propanoate

: 1421329-68-1
methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium sulfide / ethanol / 1.5 h / 90 °C / Inert atmosphere

2: methanol / 14 h / 90 °C / Inert atmosphere

3: cesium fluoride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With ammonium sulfide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; cesium fluoride; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.11.070

Reference yield:

: 1421329-53-4
methyl 3-(1-(3-bromo-4-carbamothioylphenyl)-1H-imidazol-2-yl)propanoate

: 1421329-68-1
methyl 3-(1-(3'-amino-6-(4-methoxythiazol-2-yl)biphenyl-3-yl)-1H-imidazol-2-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 14 h / 90 °C / Inert atmosphere

2: cesium fluoride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; cesium fluoride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.11.070