Technology Process of N-methyl-N-((E)-3-methyl-5-methoxyhepta-1,3,7-trien-2-yl)benzeneamine
There total 5 articles about N-methyl-N-((E)-3-methyl-5-methoxyhepta-1,3,7-trien-2-yl)benzeneamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
((E)-5-methoxy-3-methylhepta-3,6-dien-1-ynyl)-trimethylsilane;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
With
mercury(II) diacetate;
In
tetrahydrofuran;
at 20 ℃;
for 0.25h;
N-methylaniline;
With
triethylamine;
In
tetrahydrofuran;
Heating;
DOI:10.1021/jo049003a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 92 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C
2.1: 95 percent / diethyl ether; tetrahydrofuran / 10 h / 0 °C
3.1: 72 percent / KOH / 1 h / Heating
4.1: TBAF / tetrahydrofuran / 0.17 h / 20 °C
4.2: Hg(OAc)2 / tetrahydrofuran / 0.25 h / 20 °C
4.3: 48 percent / NEt3 / tetrahydrofuran / Heating
With
potassium hydroxide; tetrabutyl ammonium fluoride; Dess-Martin periodane;
In
tetrahydrofuran; diethyl ether; dichloromethane;
2.1: Grignard reaction;
DOI:10.1021/jo049003a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 95 percent / diethyl ether; tetrahydrofuran / 10 h / 0 °C
2.1: 72 percent / KOH / 1 h / Heating
3.1: TBAF / tetrahydrofuran / 0.17 h / 20 °C
3.2: Hg(OAc)2 / tetrahydrofuran / 0.25 h / 20 °C
3.3: 48 percent / NEt3 / tetrahydrofuran / Heating
With
potassium hydroxide; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; diethyl ether;
1.1: Grignard reaction;
DOI:10.1021/jo049003a