Chemical Property of CID 16219288
Chemical Property:
- Appearance/Colour:solid
- Melting Point:187oC
- PSA：95.75000
- Density:1.388 g/cm3
- LogP:1.50410
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:4
- Exact Mass:334.08374649
- Heavy Atom Count:22
- Complexity:546
- Purity/Quality:
-
99%, *data from raw suppliers
Dipyrone *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
42/43
- Safety Statements:
36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N(C)CS(=O)(=O)O.[Na]
-
Description
Dipyrone is a water soluble pyrazolone derivative available in oral,
rectal and injectable forms. It has analgesic, antipyretic,
antispasmodic, and anti-inflammatory properties.
Dipyrone is used most commonly to treat severe pain, particularly,
for pain associated with smooth muscle spasm or colic affecting the
gastrointestinal, biliary or urinary tracts. It is useful for fever
that is refractory to other treatment. Because of the risk of
serious adverse effects, such as agranulocytosis, its use is
justified only in serious situations where no alternative is
available or suitable.
-
Uses
It has the effect of detoxification, analgesic and anti-rheumatic etc and mainly used for cooling, but also can be applied to cure the acute arthritis, rheumatic pain, muscle pain and headache etc. A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models. Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively sel
ective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. Methamizole sodium has expressed analgesic and fever-reducing properties and poorly
expressed anti-inflammatory action, and is very convenient in cases where high concentrations of drug need to be quickly reached. Methamizole sodium is used for relieving
pain of various origins (renal and biliary colic, neuralgia, myalgia, trauma, burns,
headaches, and toothaches). Use of this drug may cause allergic reactions, and long-term
use may cause granulocytopenia.
