(4-methylphenyl)-glycine hydrochloride

Base Information

• Chemical Name: (4-methylphenyl)-glycine hydrochloride
• CAS No.: 134722-06-8
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 201.653
• Mol file: 134722-06-8.mol

Synonyms:(4-methylphenyl)-glycine hydrochloride

Chemical Property of (4-methylphenyl)-glycine hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2-(4-methylphenyl)aceticacid;hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-methylphenyl)-glycine hydrochloride

There total 4 articles about (4-methylphenyl)-glycine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-Boc-amino-(4'-methylphenyl)acetonitrile (774225-33-1) → (4-methylphenyl)-glycine hydrochloride (134722-06-8,1204705-08-7)

Guidance literature:

With hydrogenchloride; In water; Heating;

DOI:10.1081/SCC-200028592

Reference yield: 63.0%

tert-Butoxycarbonylamino-p-tolyl-acetic acid tert-butyl ester (111652-11-0) → (4-methylphenyl)-glycine hydrochloride (134722-06-8,1204705-08-7)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

Reference yield:

potassium cyanide + tert-butyl (phenylsulfonyl(p-tolyl)methyl)carbamate (479423-27-3) → (4-methylphenyl)-glycine hydrochloride (134722-06-8,1204705-08-7)

Guidance literature:

potassium cyanide; tert-butyl (phenylsulfonyl(p-tolyl)methyl)carbamate; With quinine; In dichloromethane; at -10 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In water; at 60 ℃; for 16h;

DOI:10.1002/adsc.200800798

upstream raw materials:

tert-Butoxycarbonylamino-p-tolyl-acetic acid tert-butyl ester

N-Boc-amino-(4'-methylphenyl)acetonitrile

tert-butyl (phenylsulfonyl(p-tolyl)methyl)carbamate

Downstream raw materials:

N-benzoyl-C-(4-methylphenyl)-glycine