ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

Base Information

Chemical Name:ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate
CAS No.:1330574-20-3
Molecular Formula:C₂₅H₂₂F₃NO₄S
Molecular Weight:489.515
Hs Code.:

Synonyms:ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

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Chemical Property of ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

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Technology Process of ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

There total 4 articles about ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1312447-92-9
N-Ts-4-trifluoromethyl-2-phenylaniline

: 140-88-5,9003-32-1
ethyl acrylate

: 1330574-20-3
ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

Guidance literature:: With dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 5h; regioselective reaction;
DOI:10.1002/asia.201100024

Reference yield:

: 917381-61-4
5-(trifluoromethyl)-[1,1′-biphenyl]-2-amine

: 1330574-20-3
ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 0 - 25 °C

2: dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid / dichloromethane / 5 h / 25 °C

With pyridine; dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/asia.201100024

Reference yield:

: 57946-63-1
4-amino-3-bromobenzotrifluoride

: 1330574-20-3
ethyl 2-(2-(trifluoromethyl)-5,6-dihydro-5-tosylphenanthridin-6-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; N,N-dimethyl-formamide / 48 h / 80 °C

2: pyridine / 1 h / 0 - 25 °C

3: dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid / dichloromethane / 5 h / 25 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; dipotassium peroxodisulfate; palladium diacetate; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/asia.201100024