8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

Base Information

Chemical Name:8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline
CAS No.:1319735-40-4
Molecular Formula:C₂₆H₂₂FN
Molecular Weight:367.466
Hs Code.:

Synonyms:8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

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Chemical Property of 8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

Chemical Property:

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Technology Process of 8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

There total 4 articles about 8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1319735-14-2
1-(4,5-dimethoxy-2-pent-1-ynylbenzyl)-1H-indole

: diphenyliodonium tetrafluoroborate

: 1319735-40-4
8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

Guidance literature:: With 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene hydrochloride; palladium diacetate; caesium carbonate; In chlorobenzene; at 30 ℃; Inert atmosphere;
DOI:10.1039/c1cc13094c

Reference yield:

: 54370-00-2
2-bromo-4,5-dimethoxybenzyl alcohol

: 1319735-40-4
8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; phosphorus tribromide / chloroform / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: copper(l) iodide; palladium diacetate; diisopropylamine; triphenylphosphine / 15 h / 100 °C / Inert atmosphere

4.1: 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene hydrochloride; palladium diacetate; caesium carbonate / chlorobenzene / 30 °C / Inert atmosphere

With pyridine; copper(l) iodide; 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene hydrochloride; palladium diacetate; phosphorus tribromide; sodium hydride; caesium carbonate; diisopropylamine; triphenylphosphine; In chloroform; N,N-dimethyl-formamide; chlorobenzene; mineral oil;
DOI:10.1039/c1cc13094c

Reference yield:

: 1314797-89-1
1-(2-bromo-4,5-dimethoxybenzyl)-1H-indole

: 1319735-40-4
8-fluoro-11-[1-phenylbut-(Z)-ylidene]-6,11-dihydroindolo[1,2-b]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; palladium diacetate; diisopropylamine; triphenylphosphine / 15 h / 100 °C / Inert atmosphere

2: 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene hydrochloride; palladium diacetate; caesium carbonate / chlorobenzene / 30 °C / Inert atmosphere

With copper(l) iodide; 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene hydrochloride; palladium diacetate; caesium carbonate; diisopropylamine; triphenylphosphine; In chlorobenzene;
DOI:10.1039/c1cc13094c