Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

Base Information

• Chemical Name: Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester
• CAS No.: 117120-89-5
• Molecular Formula: C₁₉H₂₆N₄O₄
• Molecular Weight: 374.44
• Mol file: 117120-89-5.mol

Synonyms:Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

Chemical Property of Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester

There total 3 articles about Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(1-phenyl-1H-imidazole-4,5-diyl)-bis-methanol (33457-06-6) + Isopropyl isocyanate (1795-48-8) → Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester (117120-89-5)

Guidance literature:

With dibutyltin diacetate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm00121a023

Reference yield:

diethyl 1-phenyl-1H-imidazole-4,5-dicarboxylate (117121-01-4) → Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester (117120-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / a) 0 - 5 deg C, 3 h, b) room temperature, 1 h

2: 86 percent / dibutyltin diacetate / CH₂Cl₂ / 3 h / Ambient temperature

With lithium aluminium tetrahydride; dibutyltin diacetate; In diethyl ether; dichloromethane;

DOI:10.1021/jm00121a023

Reference yield:

diethyl 2-mercapto-1-phenylimidazole-4,5-dicarboxylate (117121-07-0) → Isopropyl-carbamic acid 5-isopropylcarbamoyloxymethyl-3-phenyl-3H-imidazol-4-ylmethyl ester (117120-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / conc. nitric acid, sodium nitrite / H₂O / 1 h / 33 - 38 °C

2: 65 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / a) 0 - 5 deg C, 3 h, b) room temperature, 1 h

3: 86 percent / dibutyltin diacetate / CH₂Cl₂ / 3 h / Ambient temperature

With lithium aluminium tetrahydride; dibutyltin diacetate; nitric acid; sodium nitrite; In diethyl ether; dichloromethane; water;

DOI:10.1021/jm00121a023

upstream raw materials:

(1-phenyl-1H-imidazole-4,5-diyl)-bis-methanol

Isopropyl isocyanate

diethyl 1-phenyl-1H-imidazole-4,5-dicarboxylate

diethyl 2-mercapto-1-phenylimidazole-4,5-dicarboxylate