(R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

Base Information

Chemical Name:(R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester
CAS No.:157435-84-2
Molecular Formula:C₁₇H₂₃NO₆S
Molecular Weight:369.439
Hs Code.:

Synonyms:(R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

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Chemical Property of (R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

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Technology Process of (R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

There total 9 articles about (R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15026-17-2
succinic acid mono-tert-butyl ester

: 157435-84-2
(R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

2: 90 percent / H₂ / S-Ru-BINAP / methanol; tetrahydrofuran / 20 h / 65 °C / 2585.7 Torr

3: 1.) Me₃Al / 1.) CH₂Cl₂, hexane, ice bath cooling to r.t., 1 h, 2.) CH₂Cl₂, overnight

4: 90 percent / PPh₃, CCl₄, Et₃N / acetonitrile

5: H₂ / 10percent Pd/C / methanol / 1.5 h

6: Et₃N / CH₂Cl₂ / 0.5 h

With tetrachloromethane; hydrogen; trimethylaluminum; triethylamine; triphenylphosphine; palladium on activated charcoal; S-Ru-BINAP; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00096a031

Reference yield:

: 93740-92-2
Hexanedioic acid 3-oxo-1-methyl-6-(1,1-dimethylethyl)ester

: 157435-84-2
(R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / H₂ / S-Ru-BINAP / methanol; tetrahydrofuran / 20 h / 65 °C / 2585.7 Torr

2: 1.) Me₃Al / 1.) CH₂Cl₂, hexane, ice bath cooling to r.t., 1 h, 2.) CH₂Cl₂, overnight

3: 90 percent / PPh₃, CCl₄, Et₃N / acetonitrile

4: H₂ / 10percent Pd/C / methanol / 1.5 h

5: Et₃N / CH₂Cl₂ / 0.5 h

With tetrachloromethane; hydrogen; trimethylaluminum; triethylamine; triphenylphosphine; palladium on activated charcoal; S-Ru-BINAP; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00096a031

Reference yield:

: 157435-79-5
(S)-Hexanedioic acid 3-hydroxy-1-methyl-6-(1,1-dimethylethyl)ester

: 157435-84-2
(R)-2-Azetidinepropanoic acid 1-<<(4-methylphenyl)sulfonyl>oxy>-4-oxo-2-(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Me₃Al / 1.) CH₂Cl₂, hexane, ice bath cooling to r.t., 1 h, 2.) CH₂Cl₂, overnight

2: 90 percent / PPh₃, CCl₄, Et₃N / acetonitrile

3: H₂ / 10percent Pd/C / methanol / 1.5 h

4: Et₃N / CH₂Cl₂ / 0.5 h

With tetrachloromethane; hydrogen; trimethylaluminum; triethylamine; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo00096a031