9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one

Base Information

• Chemical Name: 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one
• CAS No.: 166883-88-1
• Molecular Formula: C₁₄H₁₅ClFNO
• Molecular Weight: 267.731

Synonyms:9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one

Chemical Property of 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one

Chemical Property:

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Technology Process of 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one

There total 1 articles about 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) + dimedone (126-81-8) → 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one (166883-88-1)

Guidance literature:

With 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In benzene; Heating;

DOI:10.1016/S0040-4020(01)89304-2

Reference yield: 96.0%

4-[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]benzonitrile (31316-87-7) + 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one (166883-88-1) → 4-(5a-((3-chloro-4-fluorophenyl)amino)-9-hydroxy-7,7-dimethyl-11-oxo-5a,6,7,8,10,11-hexahydroindeno[1,2-b]chromen-10-yl)benzonitrile

Guidance literature:

at 80 ℃; for 0.5h; Reagent/catalyst; Ionic liquid;

DOI:10.1016/j.tetlet.2018.03.014

Reference yield: 96.0%

4-methyl-benzaldehyde (104-87-0) + 9-bromo-2-(3-chloro-4-fluorophenyl)-4,4-dimethyl-4,5-dihydropyrrolo[2,3,4-kl]acridin-1(2H)-one (166883-88-1) + malononitrile (109-77-3) → 2-amino-1-(3-chloro-4-fluorophenyl)-7,7-dimethyl-1,4,5,6,7,8-hexahydro-4-(4-methylphenyl)-5-oxo-quinoline-3-carbonitrile (1032467-73-4)

Guidance literature:

at 160 ℃; for 0.333333h;

DOI:10.1080/00397910801916397

upstream raw materials:

3-chloro-4-fluorophenylamine

dimedone

Downstream raw materials:

3-[(3-Chloro-4-fluoro-phenyl)-methyl-amino]-5,5-dimethyl-cyclohex-2-enone

2-amino-4-(2-chlorophenyl)-1-(3-chloro-4-fluorophenyl)-7,7-dimethyl-1,4,5,6,7,8-hexahydro-5-oxo-quinoline-3-carbonitrile

2-amino-1-(3-chloro-4-fluorophenyl)-7,7-dimethyl-1,4,5,6,7,8-hexahydro-4-(4-methylphenyl)-5-oxo-quinoline-3-carbonitrile

2-amino-1-(3-chloro-4-fluorophenyl)-7,7-dimethyl-1,4,5,6,7,8-hexahydro-4-(3-nitrophenyl)-5-oxo-quinoline-3-carbonitrile

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