(R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Base Information

Chemical Name:(R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid
CAS No.:104260-40-4
Molecular Formula:C₂₃H₃₃N₃O₅S
Molecular Weight:463.598
Hs Code.:

Synonyms:(R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

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Chemical Property of (R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

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Technology Process of (R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

There total 8 articles about (R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100276-99-1,100277-00-7,104260-25-5
(R)-3-<(S)-ω-amino-1-ethoxycarbonylpentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

: 104260-40-4
(R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Guidance literature:: With sodium hydroxide; sodium cyanoborohydride; In ethanol; cyclohexanone;

Reference yield:

: 4443-26-9
6-phthalimidohexanoic acid

: 104260-40-4
(R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / Br₂, red P / CCl₄ / 80 deg C, 30 min, reflux 8 h

2: 95 percent / H₂SO₄

3: 42 percent / Et₃N / acetonitrile / 45 h / Heating

4: 1.) N₂H₄*H₂O; 2.) NaHCO₃ / 1.) EtOH, overnight; 2.) water, AcOEt, 30 min

5: 94 percent / 5N HCl / ethyl acetate / 3 h

6: 1.) NaBH₃CN; 2.) 1N NaOH / 1.) EtOH; 2.) water, 1 h

With hydrogenchloride; phosphorus; sodium hydroxide; sulfuric acid; bromine; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In tetrachloromethane; ethyl acetate; acetonitrile;
DOI:10.1248/cpb.34.2078

Reference yield:

: 5107-16-4
(R)-2-bromo-6-phthalimidohexanoic acid

: 104260-40-4
(R)-3-<(S)-1-carboxy-5-cyclohexylaminopentyl>amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂SO₄

2: 42 percent / Et₃N / acetonitrile / 45 h / Heating

3: 1.) N₂H₄*H₂O; 2.) NaHCO₃ / 1.) EtOH, overnight; 2.) water, AcOEt, 30 min

4: 94 percent / 5N HCl / ethyl acetate / 3 h

5: 1.) NaBH₃CN; 2.) 1N NaOH / 1.) EtOH; 2.) water, 1 h

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium cyanoborohydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In ethyl acetate; acetonitrile;
DOI:10.1248/cpb.34.2078