7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one

Base Information

• Chemical Name: 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one
• CAS No.: 1338325-75-9
• Molecular Formula: C₃₁H₃₁FN₂O₄
• Molecular Weight: 514.597
• Mol file: 1338325-75-9.mol

Synonyms:7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one

Chemical Property of 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one

There total 5 articles about 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

7-(4-bromobutoxy)-4-phenylchroman-2-one (1338325-78-2) + 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride (84163-13-3) → 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one (1338325-75-9)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 12h; Reflux;

Reference yield: 55.1%

7-(4-bromobutoxy)-4-phenylchroman-2-one (1338325-78-2) + 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole (84163-77-9) → 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one (1338325-75-9)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 6h; Reflux;

DOI:10.1021/jm400408r

Reference yield:

Cinnamic acid (621-82-9) → 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-4-phenylchroman-2-one (1338325-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; water / 6 h / Reflux

2: potassium carbonate / acetone / 6 h / Reflux

3: potassium iodide; potassium carbonate / acetonitrile / 6 h / Reflux

With hydrogenchloride; potassium carbonate; potassium iodide; In methanol; water; acetone; acetonitrile;

DOI:10.1021/jm400408r

upstream raw materials:

Cinnamic acid

7-(4-bromobutoxy)-4-phenylchroman-2-one

6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

recorcinol