N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

Base Information

Chemical Name:N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester
CAS No.:87016-25-9
Molecular Formula:C₃₂H₄₇F₃N₆O₉
Molecular Weight:716.755
Hs Code.:

N<sup>α</sup>-Boc-asparaginyl-leucyl-N<sup>ε</sup>-(trifluoroacetyl)lysyl-glycine benzyl ester

Synonyms:N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

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Technology Process of N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

There total 7 articles about N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

: 4587-33-1,104199-82-8
N-BOC-L-asparagine-p-nitrophenyl ester

: [(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-6-(2,2,2-trifluoro-acetylamino)-hexanoylamino]-acetic acid benzyl ester

: 87016-25-9
N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: 87016-25-9
N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69.2 percent / 4-methylmorpholine / dimethylformamide / 1) -15 deg C, 2 h; 2) 20 deg C, 4 h.

2: trifluoroacetic acid / 0.17 h / Ambient temperature

3: 98.3 percent / triethylamine / dimethylformamide / 24 h / 20 °C

With 4-methyl-morpholine; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 3392-09-4,60111-76-4,74124-83-7
Boc-leucine N-hydroxysuccinimide ester

: 87016-25-9
N^α-Boc-asparaginyl-leucyl-N^ε-(trifluoroacetyl)lysyl-glycine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94.5 percent / triethylamine / dimethylformamide / 5 h / 20 °C

2: 4-methylmorpholine / dimethylformamide / 0.25 h / -15 °C

3: 69.2 percent / 4-methylmorpholine / dimethylformamide / 1) -15 deg C, 2 h; 2) 20 deg C, 4 h.

4: trifluoroacetic acid / 0.17 h / Ambient temperature

5: 98.3 percent / triethylamine / dimethylformamide / 24 h / 20 °C

With 4-methyl-morpholine; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;