N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide
CAS No.:1372262-53-7
Molecular Formula:C₂₄H₂₈N₆O₅S
Molecular Weight:512.59
Hs Code.:

Synonyms:N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

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Chemical Property of N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

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Technology Process of N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

There total 5 articles about N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: C₃₁H₃₄N₆O₇S₂

: 1372262-53-7
N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

Guidance literature:: With water; sodium hydroxide; In methanol; at 40 ℃; for 10h;
DOI:10.1016/j.bioorg.2020.104092

Reference yield:

: 394-47-8
2-fluorobenzonitrile

: 1372262-53-7
N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / acetonitrile / 10 h / 80 °C

2: borane-THF / tetrahydrofuran / 60 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / butan-1-ol / 5 h / 100 °C

4: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane / 90 °C / Inert atmosphere

5: water; sodium hydroxide / methanol / 10 h / 40 °C

With borane-THF; water; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile; butan-1-ol; 4: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bioorg.2020.104092

Reference yield:

: 1372263-39-2
N-(2-(((2-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

: 1372262-53-7
N-methyl-N-(2-(((2-((3,4,5-trimethoxyphenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane / 90 °C / Inert atmosphere

2: water; sodium hydroxide / methanol / 10 h / 40 °C

With water; palladium diacetate; caesium carbonate; sodium hydroxide; XPhos; In 1,4-dioxane; methanol; 1: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bioorg.2020.104092