4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

Base Information

Chemical Name:4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile
CAS No.:1326231-48-4
Molecular Formula:C₃₀H₂₁F₄N₇O₃
Molecular Weight:603.535
Hs Code.:

Synonyms:4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

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Chemical Property of 4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

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Technology Process of 4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

There total 3 articles about 4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1326231-35-9
C₂₀H₉ClF₃N₅O₃

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 1326231-48-4
4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

Guidance literature:: With potassium carbonate; In 1,4-dioxane; Reflux;
DOI:10.1016/j.jfluchem.2011.06.021

Reference yield:

: 1326231-31-5
4-[4,6-dichloro-1,3,5-triazin-2-ylamino]-2-trifluoromethyl-benzonitrile

: 1326231-48-4
4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 8 h / 45 °C

2: potassium carbonate / 1,4-dioxane / Reflux

With sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; mineral oil;
DOI:10.1016/j.jfluchem.2011.06.021

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1326231-48-4
4-[4-[4-(2-fluorophenyl)piperazin-1-yl]-6-(2-oxo-2H-chromen-4-yloxy)-[1,3,5]triazin-2-ylamino]-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3 h / 0 - 5 °C

1.2: 6 h

2.1: sodium hydride / tetrahydrofuran; mineral oil / 8 h / 45 °C

3.1: potassium carbonate / 1,4-dioxane / Reflux

With sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; mineral oil;
DOI:10.1016/j.jfluchem.2011.06.021