(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

Base Information

Chemical Name:(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
CAS No.:78342-42-4
Molecular Formula:C9H16N2O2
Molecular Weight:184.238
Hs Code.:29335995
European Community (EC) Number:680-195-2
DSSTox Substance ID:DTXSID30999695
Nikkaji Number:J922.366E
Wikidata:Q72464866
ChEMBL ID:CHEMBL169371
Mol file:78342-42-4.mol

Synonyms:78342-42-4;(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine;(2S)-(+)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISOPROPYLPYRAZINE;(S)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine;(2s)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine;Pyrazine, 2,5-dihydro-3,6-dimethoxy-2-(1-methylethyl)-, (2S)-;(2S)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine;(2S)-3,6-dimethoxy-2-propan-2-yl-2,5-dihydropyrazine;MFCD00066229;(S)-2,5-dihydro-3,6-dimethoxy-2-iso-propylpyrazine;(2S)-2,5-dihydro-3,6-dimethoxy-2-isopropylpyrazine;79586-96-2;SCHEMBL369237;CHEMBL169371;DTXSID30999695;FCFWEOGTZZPCTO-QMMMGPOBSA-N;AKOS015851530;AC-1374;DS-12920;AM20090808;CS-0008324;A839401;W-203802;(S)-2,5-DIHYDRO-3,6-DIMETHOXY-2-ISO-PROP;(S)-2,5-dihydro-3,6-dimethoxy-2-isopropyl pyrazine;(2S)-2,5-Dihydro-3,6-dimethoxy-2-(1-methylethyl)pyrazine;(3s)-3,6-dihydro-2,5-dimethoxy-3-(1-methylethyl) pyrazine;(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine, >=97.0% (GC)

Suppliers and Price of (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
10g
$ 875.00

Sigma-Aldrich
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine ≥97.0% (GC)
1ml
$ 148.00

Medical Isotopes, Inc.
(S)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine
1 g
$ 290.00

Chem-Impex
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine,≥97%(GC) ≥97%(GC)
1ML
$ 154.92

Chemenu
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 95%+
5g
$ 421.00

Chemenu
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 95%+
1g
$ 117.00

Chemenu
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine 95%+
10g
$ 701.00

Biosynth Carbosynth
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
25 g
$ 1250.00

Biosynth Carbosynth
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
10 g
$ 750.00

Biosynth Carbosynth
(S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine
2 g
$ 210.00

Total 54 raw suppliers

Chemical Property of (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

Chemical Property:

Appearance/Colour:Clear colorless to pale yellow liquid
Vapor Pressure:0.0456mmHg at 25°C
Refractive Index:1.503
Boiling Point:245.2 °C at 760 mmHg
PKA:3.81±0.60(Predicted)
Flash Point:85.6 °C
PSA：43.18000
Density:1.09 g/cm³
LogP:-0.01440
Storage Temp.:Store below +30°C.
Solubility.:Chloroform (Slightly), DMSO (Slightly), Ethanol (Sparingly), Methanol (Slightly)
XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:184.121177757
Heavy Atom Count:13
Complexity:234

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: S23:; S24/25:;

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)C1C(=NCC(=N1)OC)OC
Isomeric SMILES:CC(C)[C@H]1C(=NCC(=N1)OC)OC
Uses (S)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine is a Sch?llkopf reagent used in the asymmetric synthesis of chiral amino acids.

Technology Process of (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine

There total 8 articles about (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 420-37-1
trimethoxonium tetrafluoroborate

: 16944-60-8
(2S)-isopropylpiperazine-3,6-dione

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Guidance literature:: In dichloromethane; for 72h; Ambient temperature;

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / tetrahydrofuran; toluene / 4 h / 50 - 60 °C

2: Et₃N / CHCl₃; tetrahydrofuran / 13 h / -78 - -20 °C

3: toluene / 24 h / Heating

4: 45 g / CH₂Cl₂ / 72 h

With triethylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene;
DOI:10.1016/S0957-4166(97)00623-X

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 78342-42-4
(S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2.1: triethylamine / dichloromethane / 0.5 h

2.2: 18 h / 20 °C

3.1: 1,2-dichloro-benzene / 18 h / 175 - 180 °C

4.1: dichloromethane / 84 h / 20 °C

With triethylamine; In dichloromethane; 1,2-dichloro-benzene;
DOI:10.1021/op049777t