2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Base Information

Chemical Name:2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione
CAS No.:1425943-04-9
Molecular Formula:C₂₇H₁₈Cl₂F₃NO₃
Molecular Weight:532.346
Hs Code.:

Synonyms:2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

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Chemical Property of 2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

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Technology Process of 2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

There total 7 articles about 2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1425943-02-7
4-bromo-2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan

: 1425943-03-8
2-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]isoindoline-1,3-dione

: 1425943-04-9
2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Guidance literature:: With potassium phosphate; C₃₄H₄₇ClNO₂PPd*C₅H₁₂O; In water; toluene; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1425942-93-3
2-(3,5-dichlorophenyl)-1,1,1-trifluoro-but-3-en-2-ol

: 1425943-04-9
2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: dicarbonylacetylacetonato rhodium (I); hydrogen; (2-oxo-1,2-dihydro-6-pyridyl)diphenylphosphine / toluene / 22 h / 80 °C / 15001.5 Torr / Inert atmosphere

2: pyridinium p-toluenesulfonate / Heating

3: bromine / dichloromethane / 0.33 h / -78 - 20 °C / Inert atmosphere

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.33 h / 100 °C / Inert atmosphere

5: C₃₄H₄₇ClNO₂PPd*C₅H₁₂O; potassium phosphate / toluene; water / 18 h / 100 °C / Inert atmosphere

With potassium phosphate; dicarbonylacetylacetonato rhodium (I); C₃₄H₄₇ClNO₂PPd*C₅H₁₂O; hydrogen; bromine; pyridinium p-toluenesulfonate; (2-oxo-1,2-dihydro-6-pyridyl)diphenylphosphine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 101422-65-5
2-[1-(4-bromophenyl)ethyl]isoindoline-1,3-dione

: 1425943-04-9
2-[1-[4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

2: C₃₄H₄₇ClNO₂PPd*C₅H₁₂O; potassium phosphate / toluene; water / 18 h / 100 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; C₃₄H₄₇ClNO₂PPd*C₅H₁₂O; potassium acetate; In water; N,N-dimethyl-formamide; toluene;