trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

Base Information

Chemical Name:trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl
CAS No.:1235892-24-6
Molecular Formula:C₂₃H₃₄F₂O₂
Molecular Weight:380.519
Hs Code.:

Synonyms:trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

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Chemical Property of trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

Chemical Property:

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Technology Process of trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

There total 8 articles about trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 4'-(4-butoxy-2,3-difluorophenyl)-bicyclohexyl-trans-4-carbaldehyde

: 1235892-24-6
trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - -10 ℃; for 2h;

Reference yield:

: 1277641-39-0
8-(4-hexyloxy-2,3-difluorophenyl)-1,4-dioxaspiro[4.5]decane

: 1235892-24-6
trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid / toluene / 2 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -10 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

3.1: formic acid / toluene / 2 h / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C

With lithium aluminium tetrahydride; formic acid; potassium tert-butylate; In tetrahydrofuran; toluene;

Reference yield:

: 136239-66-2
2,3-difluorophenyl butyl ether

: 1235892-24-6
trans-4'-(4-butoxy-2,3-difluorophenyl)-trans-4-hydroxymethylbicyclohexyl

Guidance literature:: Multi-step reaction with 8 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane; hexane / 2 h / -74 - -70 °C / Inert atmosphere

1.2: 8 h / -75 - -70 °C / Inert atmosphere

1.3: 2 h / Reflux

2.1: sec.-butyllithium / tetrahydrofuran / 2 h / -74 - -70 °C / Inert atmosphere

2.2: 8 h / -74 - -65 °C / Inert atmosphere

2.3: 2 h / 25 - 30 °C / Inert atmosphere

3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane; hexane / 2 h / -74 - -70 °C / Inert atmosphere

3.2: 8 h / -75 - -70 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux

4.2: 20 °C

5.1: formic acid / toluene / 2 h / Reflux

6.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -30 - -10 °C / Inert atmosphere

6.2: 2 h / Inert atmosphere; Reflux

7.1: formic acid / toluene / 2 h / Reflux

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 - -10 °C

With lithium aluminium tetrahydride; formic acid; potassium tert-butylate; sec.-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; cyclohexane; toluene;