methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Base Information

Chemical Name:methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride
CAS No.:1376436-79-1
Molecular Formula:C₃₇H₅₁N₃O₄*ClH
Molecular Weight:638.291
Hs Code.:

Synonyms:methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Suppliers and Price of methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

There total 7 articles about methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1376436-87-1
2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizine-7-carboxylic acid

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 1376436-79-1
methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Guidance literature:: 2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizine-7-carboxylic acid; methyl (2S)-pyrrolidine carboxylate; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 18h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

: 1376436-76-8
2-methyl-4-[(1-methylethoxy)carbonyl]-1-(2-oxohexyl)pyridinium bromide

: 1376436-79-1
methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / isopropyl alcohol / 1.5 h / Reflux

2: 4.5 h / 85 °C

3: potassium carbonate; potassium iodide / acetonitrile / 72 h / Reflux

4: water; sodium hydroxide / 1,4-dioxane / 72 h / 5 - 25 °C

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 25 °C / Inert atmosphere

With water; sodium carbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; In 1,4-dioxane; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1376436-80-4
1-methylethyl 2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizine-7-carboxylate

: 1376436-79-1
methyl (S)-1-{[2-butyl-3-({4-[3-(dibutylamino)propyl]phenyl}carbonyl)indolizin-7-yl]carbonyl}prolinate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / 1,4-dioxane / 72 h / 5 - 25 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 0 - 25 °C / Inert atmosphere

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane;