N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

Base Information

Chemical Name:N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide
CAS No.:1454904-68-7
Molecular Formula:C₁₉H₂₀Cl₂FN₃O₃
Molecular Weight:428.291
Hs Code.:

Synonyms:N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

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Chemical Property of N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

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Technology Process of N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

There total 5 articles about N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454903-99-1
N-((1R,2S)-1-(4-(6-(aminomethyl)pyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-dichloroacetamide

: 108-24-7
acetic anhydride

: 1454904-68-7
N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 1085158-52-6
5-(4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl)picolinonitrile

: 1454904-68-7
N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 16 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -40 °C

3: triethylamine / dichloromethane / 6 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 605650-21-3
2,2-dichloro-N-((1R,2S)-1-(4-(6-cyanopyridin-3-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)acetamide

: 1454904-68-7
N-((1S,2R)-2-{4-[6-(acetylaminomethyl)pyridin-3-yl]phenyl}-1-fluoromethyl-2-hydroxyethyl)-2,2-dichloroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -40 °C

2: triethylamine / dichloromethane / 6 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;