3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

Base Information

Chemical Name:3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone
CAS No.:667900-23-4
Molecular Formula:C₃₀H₃₃NO₂
Molecular Weight:439.598
Hs Code.:

Synonyms:3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

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Chemical Property of 3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

Chemical Property:

Purity/Quality:

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Technology Process of 3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

There total 6 articles about 3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2R)-6-Benzyloxy-2-[2-(4-phenyl-piperidin-1-yl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-1-ol

: 667900-23-4
3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

Guidance literature:: With Dess-Martin periodane; In dichloromethane; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2003.10.003

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 667900-23-4
3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃ / dimethylformamide

2.1: (Me₃Si)2NLi; hexamethylphosphoramide / tetrahydrofuran / 0 °C

2.2: tetrahydrofuran / 20 °C

3.1: aq. KOH / dioxane

4.1: BOP; N-methylmorpholine / dimethylformamide

5.1: lithium aluminum hydride / tetrahydrofuran

6.1: Dess-Martin periodinane / CH₂Cl₂; 2-methyl-propan-2-ol

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2003.10.003

Reference yield:

: 32263-70-0
6-benzyloxy-3,4-dihydro-2H-naphthalen-1-one

: 667900-23-4
3,4-Dihydro-6-(phenylmethoxy)-2-[2-(4-phenyl-1-piperidinyl)ethyl]-1(2H)naphthalenone

Guidance literature:: Multi-step reaction with 5 steps

1.1: (Me₃Si)2NLi; hexamethylphosphoramide / tetrahydrofuran / 0 °C

1.2: tetrahydrofuran / 20 °C

2.1: aq. KOH / dioxane

3.1: BOP; N-methylmorpholine / dimethylformamide

4.1: lithium aluminum hydride / tetrahydrofuran

5.1: Dess-Martin periodinane / CH₂Cl₂; 2-methyl-propan-2-ol

With 4-methyl-morpholine; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2003.10.003