(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

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Chemical Name:(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide
CAS No.:708197-83-5
Molecular Formula:C₄₄H₆₃N₃O₇S
Molecular Weight:778.066
Hs Code.:

(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

Synonyms:(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

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Chemical Property of (1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

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Technology Process of (1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

There total 15 articles about (1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 708197-86-8
(1R,1'S,5R,9R)-N-benzyl-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}-2-[3-oxo-1-((1'-phenylmethoxy)hexyl)-1,5,6,8a-tetrahydrooxazolo[3,4-a]pyridin-5-yl]acetamide

: 708197-83-5
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

Guidance literature:: With potassium hydroxide; In methanol; water; for 18h; Heating;
DOI:10.1021/jo049724+

Reference yield:

: [(1R,5R,8aS)-1-((S)-1-Benzyloxy-hexyl)-3,7-dioxo-8-phenylselanyl-hexahydro-oxazolo[3,4-a]pyridin-5-yl]-acetic acid methyl ester

: 708197-83-5
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / CeCl₃*7H₂O; NaBH₄ / methanol / 0.25 h

2: 91 percent / 4-dimethylaminopyridine / toluene / 3 h / Heating

3: 91 percent / AIBN; (n-Bu)3SnH / toluene / 0.08 h / Heating

4: KOH / methanol; H₂O / 2 h / 20 °C

5: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 1 h

6: 57 percent / NaOH / CH₂Cl₂ / 1.5 h

7: 80 percent / KOH / methanol; H₂O / 18 h / Heating

With dmap; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; N,N-dimethyl-formamide; In methanol; dichloromethane; water; toluene; 1: Luche reduction;
DOI:10.1021/jo049724+

Reference yield:

: 96994-77-3
3-iodopropionaldehyde dimethylacetal

: 708197-83-5
(1'R,2R,2'S,6R)-N-benzyl-2-[6-(2'-phenylmethoxy-1'-hydroxyheptyl)-1,2,3,6-tetrahydropyridin-2-yl]-N-{4-[(3,3-dimethoxypropyl)(toluene-4-sulfonyl)amino]butyl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / K₂CO₃ / acetonitrile / 16 h / Heating

2: 85 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

3: MgSO₄ / CHCl₃ / 18 h / Heating

4: 139 mg / NaBH₄ / methanol / 1 h / 20 °C

5: 57 percent / NaOH / CH₂Cl₂ / 1.5 h

6: 80 percent / KOH / methanol; H₂O / 18 h / Heating

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; magnesium sulfate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; acetonitrile;
DOI:10.1021/jo049724+