N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride

Base Information

Chemical Name:N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride
CAS No.:1360625-46-2
Molecular Formula:C₂₂H₂₅ClN₄O₂S*ClH
Molecular Weight:481.446
Hs Code.:

Synonyms:N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride

Chemical Property:

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Technology Process of N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride

There total 2 articles about N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360684-66-7
N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide

: 1360625-46-2
N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃;
DOI:10.1016/j.bmc.2011.12.039

Reference yield:

: 79322-93-3
3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine

: 347146-79-6
4-isoquinolinesulfonyl chloride

: 1360625-46-2
N-{3-[4-(4-chlorophenyl)piperazin-1-yl]propyl}-4-isoquinolinesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Cooling

2: hydrogenchloride / 1,4-dioxane; ethanol / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmc.2011.12.039