3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

Base Information

Chemical Name:3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile
CAS No.:275812-84-5
Molecular Formula:C₂₇H₃₄N₂O₈S₂
Molecular Weight:578.708
Hs Code.:

Synonyms:3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

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Chemical Property of 3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

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Technology Process of 3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

There total 4 articles about 3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 7605-28-9
2-(phenylsulfonyl)acetonitrile

: 275812-74-3
1,2-dideoxy-3,4:5,6-di-O-isopropylidene-1,2-(N-p-toluenesulfonyl)imino-D-mannitol

: 275812-84-5
3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(00)00130-1

Reference yield:

: 1-amino-1-deoxy-3,4;5,6-di-O-isopropylidene-D-glucitol p-toluenesulfonate

: 275812-84-5
3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

2: 10.5 g / Et₃N / CH₂Cl₂ / 1 h / 20 °C

3: 79 percent / NaH / tetrahydrofuran / 1 h / 20 °C

4: 87 percent / NaH / tetrahydrofuran / 24 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)00650-0

Reference yield:

: 275812-72-1
1-deoxy-3,4:5,6-di-O-isopropylidene-2-O-methanesulfonyl-1-(N-p-toluenesulfonyl)amino-D-glucitol

: 275812-84-5
3,4-dideoxy-5,6:7,8-di-O-isopropylidene-2-phenylsulfonyl-4-(N-p-toluenesulfonyl)amino-D-manno-octanitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / NaH / tetrahydrofuran / 1 h / 20 °C

2: 87 percent / NaH / tetrahydrofuran / 24 h / 20 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0040-4020(01)00650-0