((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Base Information

Chemical Name:((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester
CAS No.:934425-41-9
Molecular Formula:C₃₅H₄₄FN₃O₅
Molecular Weight:605.75
Hs Code.:

((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Synonyms:((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Chemical Property of ((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Technology Process of ((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

There total 1 articles about ((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 867305-04-2
1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-5-cyclopropyl-2-(4-fluoro-phenyl)-1H-imidazole-4-carboxylic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 934425-41-9
((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Guidance literature:: 1-[2-((4R,6R)-6-tert-Butoxycarbonylmethyl-2,2-dimethyl-[1,3]dioxan-4-yl)-ethyl]-5-cyclopropyl-2-(4-fluoro-phenyl)-1H-imidazole-4-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.333333h;

(S)-1-phenyl-ethylamine; In dichloromethane; at 20 ℃;

Reference yield: 72.0%

: 934425-41-9
((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

: 934425-42-0
(3R,5R)-7-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-3,5-dihydroxy-heptanoic acid tert-butyl ester

Guidance literature:: ((4R,6R)-6-{2-[5-Cyclopropyl-2-(4-fluoro-phenyl)-4-((S)-1-phenyl-ethylcarbamoyl)-imidazol-1-yl]-ethyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester; With hydrogenchloride; methanol; water; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; water; pH=7;