Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester

Base Information

• Chemical Name: Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester
• CAS No.: 92934-93-5
• Molecular Formula: C₁₆H₂₆O₄S
• Molecular Weight: 314.446
• Mol file: 92934-93-5.mol

Synonyms:Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester

Chemical Property of Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester

There total 10 articles about Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Toluene-4-sulfonic acid (2R,6S)-2,6-dimethyl-7-((R)-1-phenyl-ethylcarbamoyloxy)-heptyl ester (92803-70-8,92934-92-4) → Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester (92934-93-5)

Guidance literature:

With trichlorosilane; triethylamine; In benzene; at 25 ℃;

DOI:10.1139/v84-267

Reference yield: 87.0%

Toluene-4-sulfonic acid (2R,6S)-2,6-dimethyl-7-((S)-1-phenyl-ethylcarbamoyloxy)-heptyl ester (92934-92-4) → Toluene-4-sulfonic acid (2R,6S)-7-hydroxy-2,6-dimethyl-heptyl ester (92934-93-5)

Guidance literature:

With trichlorosilane; In triethylamine; benzene; for 24h; Ambient temperature;

Reference yield:

2,6-Dimethyl-1,6-heptadiene (51708-83-9) → Toluene-4-sulfonic acid (2R,6R)-7-hydroxy-2,6-dimethyl-heptyl ester (75924-59-3,92934-88-8,92934-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thexylborane / tetrahydrofuran / -78 - 25 °C

2: pyridine / 0 °C

With pyridine; thexylborane; In tetrahydrofuran;

DOI:10.1021/ja00544a049

upstream raw materials:

(2S,6S)-2,6-Dimethyl-heptane-1,7-diol

p-toluenesulfonyl chloride

2,6-Dimethyl-1,6-heptadiene

Toluene-4-sulfonic acid (2R,6S)-2,6-dimethyl-7-((R)-1-phenyl-ethylcarbamoyloxy)-heptyl ester

Downstream raw materials:

(2R,6S)-7-<(tert-butyldimethylsilyl)oxy>-2,6-dimethyl-1-heptyl p-toluenesulfonate

(S)-Methoxy-phenyl-acetic acid (2S,6S)-2,6,10-trimethyl-undecyl ester