{(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

Base Information

Chemical Name:{(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile
CAS No.:429619-38-5
Molecular Formula:C₂₃H₃₆N₂O₂
Molecular Weight:372.551
Hs Code.:

Synonyms:{(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

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Chemical Property of {(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

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Technology Process of {(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

There total 5 articles about {(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

: 429619-24-9
{(5R)-5-[(2R,4Z)-2-(benzyloxy)-8-(dimethylamino)oct-4-enyl]tetrahydrofuran-2-yl}acetonitrile

: 429619-38-5
{(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; acetic acid; for 3h;

Reference yield:

: (S)-3-Benzyloxy-4-((2R,5S)-5-iodomethyl-tetrahydro-furan-2-yl)-butyraldehyde

: 429619-38-5
{(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 95.5 percent / TsOH / benzene / 1.5 h / Heating

2.1: 97.7 percent / tetrahydrofuran / 48 h / Heating

3.1: HCl

4.1: NaN(SiMe₃)2 / toluene

4.2: 66.6 percent / toluene / -40 - 20 °C

5.1: 98.7 percent / H₂ / Pd/C (10 percent) / methanol; acetic acid / 3 h

With hydrogenchloride; hydrogen; sodium hexamethyldisilazane; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; toluene; benzene; 2.1: Kolbe's nitrile synthesis / 4.2: Wittig reaction;

Reference yield:

: 429618-16-6
2-{(S)-2-(benzyloxy)-3-[(2R,5S)-5-(iodomethyl)tetrahydrofuran-2-yl]propyl}-1,3-dioxolane

: 429619-38-5
{(5R)-5-[(2R)-2-(benzyloxy)-8-(dimethylamino)octyl]tetrahydrofuran-2-yl}acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97.7 percent / tetrahydrofuran / 48 h / Heating

2.1: HCl

3.1: NaN(SiMe₃)2 / toluene

3.2: 66.6 percent / toluene / -40 - 20 °C

4.1: 98.7 percent / H₂ / Pd/C (10 percent) / methanol; acetic acid / 3 h

With hydrogenchloride; hydrogen; sodium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; toluene; 1.1: Kolbe's nitrile synthesis / 3.2: Wittig reaction;