11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene

Base Information

• Chemical Name: 11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene
• CAS No.: 849241-61-8
• Molecular Formula: C₄₁H₅₆O₄Si
• Molecular Weight: 640.979
• Mol file: 849241-61-8.mol

Synonyms:11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene

Chemical Property of 11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene

There total 1 articles about 11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(tert-butyldimethylsilyloxy)ethyl bromide (86864-60-0) + 3,17β-bis(benzyloxy)-11α-hydroxymethylestra-1,3,5(10)-triene (534572-55-9) → 11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene (849241-61-8)

Guidance literature:

3,17β-bis(benzyloxy)-11α-hydroxymethylestra-1,3,5(10)-triene; With 18-crown-6 ether; potassium hydride; In toluene; at 20 ℃; for 0.5h;

2-(tert-butyldimethylsilyloxy)ethyl bromide; In toluene; at 60 ℃;

DOI:10.1021/jm049352x

Reference yield: 55.0%

11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene (849241-61-8) → 2-((3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)-methoxy)ethanol (849241-62-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/jm049352x

Reference yield:

11β-(tert-butyldimethylsiloxyethoxy)methyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene (849241-61-8) → 3,17β-dibenzyloxy-11β-(2-fluoroethoxymethyl)estra-1,3,5(10)-triene (849241-64-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / nBu₄NF / tetrahydrofuran / 0.5 h / 20 °C

2: 96 percent / pyridine / 4 °C

3: 15 mg / nBu₄NF / tetrahydrofuran / 0.5 h / 70 °C

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm049352x

upstream raw materials:

2-(tert-butyldimethylsilyloxy)ethyl bromide

3,17β-bis(benzyloxy)-11α-hydroxymethylestra-1,3,5(10)-triene

Downstream raw materials:

2-((3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)-methoxy)ethanol

3,17β-dibenzyloxy-11β-(2-fluoroethoxymethyl)estra-1,3,5(10)-triene

3,17β-dibenzyloxy-11β-(methanesulfonyloxyethoxymethyl)estra-1,3,5(10)-triene