N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide
CAS No.:1228465-65-3
Molecular Formula:C₂₄H₁₈F₄N₆O₃S
Molecular Weight:546.505
Hs Code.:

Synonyms:N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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Chemical Property of N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

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Technology Process of N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

There total 8 articles about N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1125632-90-7
N-{5-[(3-amino-4-fluorophenyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

: 35037-73-1
1-isocyanato-4-trifluoromethoxy-benzene

: 1228465-65-3
N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 70 ℃; for 8h;

Reference yield:

: 369-36-8
6-fluoro-3-nitroaniline

: 1228465-65-3
N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 55 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 0.58 h / 90 °C / Inert atmosphere; Microwave irradiation

4: hydrogenchloride / ethyl acetate; water / 0 °C

5: pyridine / N,N-dimethyl-formamide / 8 h / 70 °C

With pyridine; hydrogenchloride; potassium tert-butylate; hydrogen; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 5350-93-6
6-Chloro-pyridin-3-ylamine

: 1228465-65-3
N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 12 h / 85 °C / Cooling

2: tetrahydrofuran / 2 h / 0 °C

3: potassium tert-butylate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 0.58 h / 90 °C / Inert atmosphere; Microwave irradiation

4: hydrogenchloride / ethyl acetate; water / 0 °C

5: pyridine / N,N-dimethyl-formamide / 8 h / 70 °C

With pyridine; hydrogenchloride; potassium tert-butylate; bromine; acetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;