3-hydroxy-2-phenylquinolin-4(1H)-one

Base Information

• Chemical Name: 3-hydroxy-2-phenylquinolin-4(1H)-one
• CAS No.: 31588-18-8
• Molecular Formula: C15H11 N O2
• Molecular Weight: 237.258
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID80377222
• Nikkaji Number: J709.681J
• Wikidata: Q82166363
• ChEMBL ID: CHEMBL4105227
• Mol file: 31588-18-8.mol

Synonyms:3-hydroxy-2-phenylquinolin-4(1H)-one;31588-18-8;3-hydroxy-2-phenyl-4(1H)-quinolinone;3-hydroxy-2-phenyl-1H-quinolin-4-one;Dioxy-Phenylchinolin;SAFRANINEO;Oprea1_756988;SCHEMBL1627825;CHEMBL4105227;DTXSID80377222;KUC106822N;MFCD00451324;STK988537;2-Phenyl-3-hydroxy-4(1H)-quinolone;AKOS002281730;SB71995;2-phenyl-3-hydroxy-4(1h)-quinolinone;KSC-11-240-4;FT-0680390;3-hydroxy-2-phenyl-1,4-dihydroquinolin-4-one;E78342;4T-0221;A875850;J-512626

Chemical Property of 3-hydroxy-2-phenylquinolin-4(1H)-one

Chemical Property:

• Vapor Pressure: 1.62E-07mmHg at 25°C
• Melting Point: 268-270°C
• Boiling Point: 411.8°Cat760mmHg
• Flash Point: 202.8°C
• PSA: 53.09000
• Density: 1.323g/cm³
• LogP: 2.90070
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 237.078978594
• Heavy Atom Count: 18
• Complexity: 369

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-2-phenyl-4(1H)-quinolinone >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C(=O)C3=CC=CC=C3N2)O

Technology Process of 3-hydroxy-2-phenylquinolin-4(1H)-one

There total 17 articles about 3-hydroxy-2-phenylquinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-oxo-2-phenylethyl 2-formylbenzoate → 3-hydroxy-2-phenyl-1H-quinolin-4-one (31588-18-8)

Guidance literature:

With formic acid; ammonium formate; for 5h; Heating;

DOI:10.3987/COM-06-10899

Reference yield: 76.0%

anthranilic acid phenacylester (130627-10-0) → 3-hydroxy-2-phenyl-1H-quinolin-4-one (31588-18-8)

Guidance literature:

With PPA; silica gel; for 0.0333333h; microwave irradiation;

Reference yield: 65.0%

2-hydroxymethyl-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinazoline (308832-66-8) → 3-hydroxy-2-phenyl-1H-quinolin-4-one (31588-18-8)

Guidance literature:

With acetic acid; for 2h; Heating;

DOI:10.1002/jhet.5570370427

upstream raw materials:

3-H-1,2a-dihydro-2-phenyl-2a-methoxyazirino<1,2-a>indol-3-one

anthranilic acid phenacylester

2-hydroxymethyl-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinazoline

N-formylanthranilic acid

Downstream raw materials:

2-(Benzoylamino)benzoic Acid

2-phenyl-4H-3,1-benzoxazin-4-one

anthranilic acid

benzoic acid