?4-ethynyl-2-methylbenzoic acid tert-butyl ester?

Base Information Edit

Chemical Name:?4-ethynyl-2-methylbenzoic acid tert-butyl ester?
CAS No.:1425943-18-5
Molecular Formula:C₁₄H₁₆O₂
Molecular Weight:216.28
Hs Code.:
Mol file:1425943-18-5.mol

Synonyms:?4-ethynyl-2-methylbenzoic acid tert-butyl ester?

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Chemical Property of ?4-ethynyl-2-methylbenzoic acid tert-butyl ester? Edit

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Technology Process of ?4-ethynyl-2-methylbenzoic acid tert-butyl ester?

There total 4 articles about ?4-ethynyl-2-methylbenzoic acid tert-butyl ester? which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425943-17-4
2-methyl-4-trimethylsilanylethynyl-benzoic acid tert-butyl ester

: 1425943-18-5
?4-ethynyl-2-methylbenzoic acid tert-butyl ester?

Guidance literature:: With methanol; potassium carbonate; In methanol; at 20 ℃; for 0.25h;

Reference yield:

: 445003-37-2
4-bromo-2-methyl-benzoic acid tert-butyl ester

: 1425943-18-5
?4-ethynyl-2-methylbenzoic acid tert-butyl ester?

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 4 h / 45 °C / Inert atmosphere

2: potassium carbonate; methanol / methanol / 0.25 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; diisopropylamine; In tetrahydrofuran; methanol;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1425943-18-5
?4-ethynyl-2-methylbenzoic acid tert-butyl ester?

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

2: tetrahydrofuran / 5 - 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; diisopropylamine; copper(l) iodide / tetrahydrofuran / 4 h / 45 °C / Inert atmosphere

4: potassium carbonate / methanol / 0.25 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; potassium carbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol;