pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

Base Information

Chemical Name:pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide
CAS No.:1354567-46-6
Molecular Formula:C₂₄H₂₄N₄O₂
Molecular Weight:400.48
Hs Code.:

Synonyms:pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

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Chemical Property of pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

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Technology Process of pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

There total 6 articles about pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1140503-30-5
4-(3-allyloxyphenyl)-2-chloro-pyrimidine

: 937271-57-3
pent-4-enoic acid (3-aminophenyl)amide

: 1354567-46-6
pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

Guidance literature:: With hydrogenchloride; In water; butan-1-ol; at 90 - 100 ℃;
DOI:10.1021/jm201112g

Reference yield:

: 937271-43-7
3-(2-chloropyrimidine-4-yl)phenol

: 1354567-46-6
pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 20 °C

2: hydrogenchloride / water; butan-1-ol / 90 - 100 °C

With hydrogenchloride; tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In dichloromethane; water; butan-1-ol;
DOI:10.1021/jm201112g

Reference yield:

: 87199-18-6
3-hydroxyphenylboronic acid

: 1354567-46-6
pent-4-enoic acid {3-[4-(3-allyloxyphenyl)pyrimidin-2-ylamino]phenyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 7 h / 80 °C / Inert atmosphere; Alkaline aq. solution

2: tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide / dichloromethane / 20 °C

3: hydrogenchloride / water; butan-1-ol / 90 - 100 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water; butan-1-ol; 1: Suzuki coupling;
DOI:10.1021/jm201112g