1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

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Chemical Name:1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate
CAS No.:137650-27-2
Molecular Formula:C₃₂H₄₆N₂O₄
Molecular Weight:522.728
Hs Code.:

Synonyms:1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

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Chemical Property of 1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

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Technology Process of 1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

There total 5 articles about 1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2038-57-5
3-Phenylpropan-1-amine

: 137650-26-1
5(S)-<<(1,1-dimethylethoxy)carbonyl>amino>-6-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-3(E)-hexenoic acid

: 137650-27-2
1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -23 - 23 ℃; for 2.5h;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-17-0
1,1-dimethylethyl <2-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-1(S)-formylethyl>carbamate

: 137650-27-2
1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C, 1 h

2: 1.) dicyclohexylborane, 2.) H₂O₂ / 1.) THF, 0.5 h, 2.) THF, MeOH, 0.5 h

3: 89 percent / DCC, 1-hydroxybenzotriazole hydrate / dimethylformamide / 2.5 h / -23 - 23 °C

With n-butyllithium; bis(cyclohexanyl)borane; dihydrogen peroxide; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-15-8
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-2,6-dimethylphenyl)propanoate

: 137650-27-2
1,1-dimethylethyl<1(S)-<<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>methyl>-5-oxo-5-<(3-phenylpropyl)amino>-2(E)-pentenyl>carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / BF₃*Et₂O / CH₂Cl₂ / 16 h / 0 °C

2: Dibal-H / toluene / -78 °C

3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to 0 deg C, 1 h

4: 1.) dicyclohexylborane, 2.) H₂O₂ / 1.) THF, 0.5 h, 2.) THF, MeOH, 0.5 h

5: 89 percent / DCC, 1-hydroxybenzotriazole hydrate / dimethylformamide / 2.5 h / -23 - 23 °C

With n-butyllithium; boron trifluoride diethyl etherate; bis(cyclohexanyl)borane; dihydrogen peroxide; diisobutylaluminium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00080a005