N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

Base Information

Chemical Name:N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine
CAS No.:1292213-46-7
Molecular Formula:C₂₂H₂₃FN₈O
Molecular Weight:434.476
Hs Code.:

Synonyms:N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

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Chemical Property of N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

Chemical Property:

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Technology Process of N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

There total 6 articles about N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-{4-[(3-amino-propylamino)-methyl]-phenyl}-2-(4-fluoro-phenyl)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-5-one hydrochloride

: 152120-54-2,862686-58-6,1143572-00-2
N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

: 1292213-46-7
N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

Guidance literature:: With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; for 5h;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1292213-46-7
N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / toluene / 2.5 h / 80 °C

1.2: 0 - 20 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 80 °C / Inert atmosphere

4.1: sodium methylate / methanol / 50 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: hydrogenchloride / water

7.1: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 5 h

With hydrogenchloride; potassium phosphate; sodium methylate; potassium acetate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1292220-25-7
{3-[(4-bromo-benzyl)-tert-butoxycarbonyl-amino]-propyl}-carbamic acid tert-butyl ester

: 1292213-46-7
N-(3-{4-[2-(4-fluoro-phenyl)-5-oxo-3,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-benzylamino}-propyl)-guanidine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 80 °C / Inert atmosphere

3: sodium methylate / methanol / 50 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: hydrogenchloride / water

6: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 5 h

With hydrogenchloride; potassium phosphate; sodium methylate; potassium acetate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;