N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide

Base Information

• Chemical Name: N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide
• CAS No.: 1443125-01-6
• Molecular Formula: C₃₁H₄₀N₆O₃
• Molecular Weight: 544.697

Synonyms:N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide

Chemical Property of N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide

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Technology Process of N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide

There total 3 articles about N⁴,N⁴-diethyl-N¹-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethylpiperidine-4-carboxamide (1903-67-9) + bis(trichloromethyl) carbonate (32315-10-9) + C20H22N4O → N4,N4-diethyl-N1-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide (1443125-01-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.01.056

Reference yield:

C13H15N3O (1452128-54-9) → N4,N4-diethyl-N1-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide (1443125-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 - 50 °C

2: acetic acid; iron / ethanol / 5 h / 120 °C

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With iron; caesium carbonate; acetic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.01.056

Reference yield:

3-Nitrobenzyl chloride (619-23-8) → N4,N4-diethyl-N1-(3-((3-((2-isopropylphenyl)amino)-6-oxopyridazin-1(6H)-yl)methyl) phenyl)piperidine-1,4-dicarboxamide (1443125-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 - 50 °C

2: acetic acid; iron / ethanol / 5 h / 120 °C

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With iron; caesium carbonate; acetic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2013.01.056

upstream raw materials:

C₁₃H₁₅N₃O

N,N-diethylpiperidine-4-carboxamide

bis(trichloromethyl) carbonate

3-Nitrobenzyl chloride

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