3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate

Base Information

• Chemical Name: 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate
• CAS No.: 1416000-84-4
• Molecular Formula: C₂HF₃O₂*C₂₈H₃₃Cl₂F₂N₃O₈S₂
• Molecular Weight: 826.644
• Mol file: 1416000-84-4.mol

Synonyms:3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate

Chemical Property of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate

There total 3 articles about 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(vinylsulfonyl)thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide (1416002-26-0) → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate (1416000-84-4)

Guidance literature:

In ethanol; at 20 ℃; for 1h;

Reference yield:

morpholine (110-91-8,99108-56-2) + 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(vinylsulfonyl)thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide (1416002-26-0) + trifluoroacetic acid (76-05-1) → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate (1416000-84-4)

Guidance literature:

morpholine; 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(vinylsulfonyl)thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide; In ethanol; at 20 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl](2S)-thiazolidine-2-carboxylate hydrochloride (1415994-84-1) → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(2-morpholinoethylsulfonyl)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide trifluoroacetate (1416000-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 8 h / 0 - 20 °C

2: ethanol / 1 h / 20 °C

With pyridine; In ethanol; dichloromethane;

upstream raw materials:

morpholine

3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-3-(vinylsulfonyl)thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide

[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl](2S)-thiazolidine-2-carboxylate hydrochloride

trifluoroacetic acid