ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate

Base Information

• Chemical Name: ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate
• CAS No.: 1315580-24-5
• Molecular Formula: C₁₆H₁₉NO₅
• Molecular Weight: 305.331
• Mol file: 1315580-24-5.mol

Synonyms:ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate

Chemical Property of ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate

There total 3 articles about ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2-nitroethenyl)benzene (102-96-5) + 2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate (1315580-24-5)

Guidance literature:

With polystyrene supported 3-(benzylamino)-4-(((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione; In dichloromethane; at 20 ℃; for 8h; enantioselective reaction;

DOI:10.1002/ejoc.201300626

Reference yield:

nitrostyrene (5153-67-3) + 2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → ethyl 1-((1S)-2-nitro-1-phenylethyl)-2-oxocyclopentanecarboxylate (1170773-51-9) + ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate (1315580-24-5)

Guidance literature:

With (1R,2R)-N₁-(1H-benzo[d]imidazol-2-yl)-N₂,N₂-dimethyl-cyclohexane-1,2-diamine; trifluoroacetic acid; In toluene; at 0 ℃; for 6.5h;

DOI:10.1021/jo9010552

Reference yield:

(2-nitroethenyl)benzene (102-96-5) + 2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → ethyl 1-((1S)-2-nitro-1-phenylethyl)-2-oxocyclopentanecarboxylate (1170773-51-9) + ethyl 1-[(R)-2-nitro-1-phenylethyl]-2-oxocyclopentanecarboxylate (1315580-24-5)

Guidance literature:

With C₂HF₃O₂*C₃₅H₅₀N₄O; In toluene; at 0 ℃; for 12h; stereoselective reaction; Microwave irradiation;

DOI:10.1002/ejoc.201200303

upstream raw materials:

nitrostyrene

2-ethoxycarbonyl-1-cyclopentanone

(2-nitroethenyl)benzene