rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

Base Information

Chemical Name:rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one
CAS No.:950674-39-2
Molecular Formula:C₂₈H₂₅F₅O₂
Molecular Weight:488.497
Hs Code.:

Synonyms:rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

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Chemical Property of rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

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Technology Process of rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

There total 1 articles about rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 950674-38-1
rac-5-(4-fluorophenyl)-6-{hydroxy[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

: 950674-39-2
rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃;

Reference yield: 36.0%

: 950674-39-2
rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

: 950673-56-0
(4S)-5-(4-Fluorophenyl)-7-isopropyl-2,2-dimethyl-6-[4-(trifluoromethyl)benzyl]chroman-4-ol

Guidance literature:: rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one; With borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; In tetrahydrofuran; at 20 ℃; for 72h;

With methanol; In tetrahydrofuran;

Reference yield:

: 950674-39-2
rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one

: 950673-55-9
(4S)-5-(4-fluorophenyl)-6-{(R)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethylchroman-4-ol

: (4R)-5-(4-fluorophenyl)-6-{(R)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethylchroman-4-ol

: (4R)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethylchroman-4-ol

: 950673-54-8
(4S)-5-(4-fluorophenyl)-6-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethylchroman-4-ol

Guidance literature:: rac-5-(4-Fluorophenyl)-6-{fluoro[4-(trifluoromethyl)phenyl]methyl}-7-isopropyl-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one; With borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; In tetrahydrofuran; at 20 ℃; for 6.5h;

With methanol; In tetrahydrofuran;