carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester

Base Information

• Chemical Name: carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester
• CAS No.: 1350552-18-9
• Molecular Formula: C₃₈H₄₁FN₈O₈
• Molecular Weight: 756.791
• Mol file: 1350552-18-9.mol

Synonyms:carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester

Chemical Property of carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester

There total 4 articles about carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbonic acid 1-chloroethyl ester (R)-1-methylbutyl ester (1350552-19-0) + N-[1-amino-1-(4-{[[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}phenyl)methylidene]benzamide (1350551-90-4) → carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester (1350552-18-9) + carbonic acid (R)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester (1350551-44-8)

Guidance literature:

carbonic acid 1-chloroethyl ester (R)-1-methylbutyl ester; N-[1-amino-1-(4-{[[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}phenyl)methylidene]benzamide; With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 55 ℃; for 18h;

In methanol;

Reference yield:

p-nitrophenylbenzoate (959-22-8) → carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester (1350552-18-9) + carbonic acid (R)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester (1350551-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / 50 °C

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 18 h / 55 °C

2.2: SUMICHIRAL OA-2500

With potassium hydrogencarbonate; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

(R)-2-pentanol (31087-44-2,13403-73-1) → carbonic acid (S)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester (1350552-18-9) + carbonic acid (R)-1-(5-{(R)-(4-{amino[benzoylimino]methyl}phenylamino)-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxy)ethyl ester (R)-1-methylbutyl ester (1350551-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / tetrahydrofuran / -78 - 20 °C

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 18 h / 55 °C

2.2: SUMICHIRAL OA-2500

With pyridine; potassium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

p-nitrophenylbenzoate

(R)-2-pentanol

4-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate

carbonic acid 1-chloroethyl ester (R)-1-methylbutyl ester