rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:1718-82-7
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

There total 10 articles about rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1718-79-2
1-(3-benzyloxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 1718-82-7
rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 1-(3-benzyloxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline; With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1002/anie.201006268

Reference yield:

: 1718-82-7
rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 1718-82-7
S-Armepavine

: 151841-47-3
(R)-6,7-dimethoxy-1-(3-hydroxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With recombinant monoamine oxidase D₁₁ from Aspergillus niger; In aq. phosphate buffer; dimethyl sulfoxide; at 37 ℃; for 24h; pH=7.7; Reagent/catalyst; Time; Resolution of racemate; Enzymatic reaction;
DOI:10.1039/c4cy00642a

Reference yield:

: 1277187-89-9
2-(3-benzyloxyphenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide

: 1718-82-7
rac-1-(3-hydroxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / acetonitrile / 3 h / Reflux; Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 16 h / 20 °C

With palladium 10% on activated carbon; hydrogen; acetic acid; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1002/anie.201006268