2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

Base Information

Chemical Name:2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol
CAS No.:344569-46-6
Molecular Formula:C₂₄H₃₂O₃Si
Molecular Weight:396.602
Hs Code.:

2-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2<i>H</i>-pyran-3-ol

Synonyms:2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

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Chemical Property of 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

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Technology Process of 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

There total 9 articles about 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 344569-44-4
(2S,3S)-2-(3-Hydroxy-propyl)-3,6-dihydro-2H-pyran-3-ol

: 344569-46-6
2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)00440-3

Reference yield:

: 221015-49-2
(1R,2S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-ol

: 344569-46-6
2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / H₂ / PtO₂ / ethyl acetate

2: 91 percent / NaH / tetrahydrofuran; dimethylformamide

3: TBAF / tetrahydrofuran

4: I₂; PPh₃; imidazole / toluene

5: 83 percent / Zn; AcOH / methanol / 20 °C

6: 96 percent / NaBH₄ / ethanol

7: 99 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

8: 100 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; Grubbs catalyst first generation; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium hydride; acetic acid; triphenylphosphine; zinc; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)00440-3

Reference yield:

: 221015-46-9
(1S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-one

: 344569-46-6
2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / NaBH₄; CeCl₃ / methanol

2: 95 percent / H₂ / PtO₂ / ethyl acetate

3: 91 percent / NaH / tetrahydrofuran; dimethylformamide

4: TBAF / tetrahydrofuran

5: I₂; PPh₃; imidazole / toluene

6: 83 percent / Zn; AcOH / methanol / 20 °C

7: 96 percent / NaBH₄ / ethanol

8: 99 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

9: 100 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; Grubbs catalyst first generation; cerium(III) chloride; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium hydride; acetic acid; triphenylphosphine; zinc; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(01)00440-3