tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Base Information

Chemical Name:tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate
CAS No.:1335139-52-0
Molecular Formula:C₂₅H₄₃N₃O₄
Molecular Weight:449.634
Hs Code.:

Synonyms:tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Chemical Property of tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Technology Process of tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

There total 8 articles about tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₄₁N₃O₄

: 1335139-52-0
tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: With palladium 10% on activated carbon; water; hydrogen; In ethanol; at 20 ℃; for 9h; under 760.051 Torr;

Reference yield:

: 1335139-08-6
1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carbaldehyde

: 1335139-52-0
tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C

1.2: 14 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 9 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; water; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In ethanol; acetonitrile; 1.1: |Wittig-Horner Reaction / 1.2: |Wittig-Horner Reaction;

Reference yield:

: 2523-55-9
trans-4-methylcyclohexanamine

: 1335139-52-0
tert-butyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4 h / 70 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.1: sodium hydrogencarbonate; iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; toluene / 2 h / 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C

4.2: 14 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen; water / ethanol / 9 h / 20 °C / 760.05 Torr

With lithium aluminium tetrahydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; water; hydrogen; iodine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; ethanol; water; toluene; acetonitrile; 4.1: |Wittig-Horner Reaction / 4.2: |Wittig-Horner Reaction;